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It’s been more than thirty years since New York City medical examiner Jack Stapleton’s college graduation, and almost as long since he’s been in touch with former classmates Shawn Daughtry and James O’Rourke. Jack was once a highly regarded ophthalmologist, but his career took a dramatic turn after a tragic accident destroyed his family. And that, too, is very much in the past: Jack has remarried — to longtime colleague and fellow medical examiner Laurie Montgomery — and his the father of a young child, who unfortunately has been diagnosed with neuroblastoma, a childhood cancer. No matter what stresses he faces, Jack’s renegade, activist personality can’t rest. After performing a postmortem on a promising young college graduate who had recently been treated by a chiropractor, Jack begins researching alternative medicine as a way to avoid obsessing about his child’s illness. Quickly he is confronted by the question of what makes some people step outside the medical establishment to seek help from therapies based on dubious science, Eastern philosophies or even faith healers. Jack’s classmate Shawn Daughtry is now a renowned archaeologist and biblical scholar. Brash, impetuous, and completely career-driven, Shawn makes a spectacular find at a souk in Cairo: an ancient codex, whose contents may vault him to international fame. His discovery takes him on a secret journey to what is held to be Saint Peter’s tomb beneath the basilica in Rome, where he hopes to unearth a two-thousand-year-old ossuary, the contents of which may have earthshaking ecclesiastical and medical implications. Shawn can’t wait to flaunt his treasure before his old college buddy James O’Rourke — now James Cardinal O’Rourke, bishop of the Archdiocese of New York: the treasure may jeopardize the very nature of papal infallibility. Desperate to protect his church and his own political ambitions, James turns to his friend Jack to help safeguard an explosive secret, one with the power to change lives forever.

When an unidentified, seemingly healthy young woman collapses suddenly on the New York City subway and dies upon reaching the hospital, her case is an eerie reminder for veteran medical examiner Jack Stapleton of the 1918 flu pandemic. Fearful of a repeat on the one hundredth anniversary of the nightmarish contagion, Jack autopsies the woman within hours of her demise and discovers some striking anomalies: first, that she has had a heart transplant, and second, that, against all odds, her DNA matches that of the transplanted heart. Although the facts don’t add up to influenza, Jack must race against the clock to identify the woman and determine what kind of virus could wreak such havoc — a task made more urgent when two other victims succumb to a similar rapid death. But nothing makes sense until his investigation leads him into the fascinating realm of CRISPR/CAS9, a gene-editing biotechnology that’s captured the imagination of the medical community... and the attention of its most unethical members. Drawn into the dark underbelly of the organ transplant market, Jack will come face-to-face with a megalomaniacal businessman willing to risk human lives in order to conquer a lucrative new frontier in medicine — and if Jack’s not careful, the next life lost might be his own.

The man who invented medical techno-horror takes you on a startling and chilling odyssey into the origins of life — and death. When an eminent biomolecular geneticist dies violently before his eyes, a doctor must use more than his medical knowledge to explain what he comes to believe is murder, and to stop a scientific breakthrough from becoming a curse instead of a miracle. There was a lot that internist Jason Howard didn’t know about Dr. Alvin Hayes. But when the scientist met his sudden end, it all came out with a vengeance — for the academically respected geneticist had led a double life, and the private side was damning. Dismissing official police reports linking Hayes’s death to his associations with the sordid side of society, Jason believes Hayes was silenced to keep him from revealing the results of his research, and the secret lies not in the back streets of Boston’s erotic underworld, the Combat Zone, but in the high-tech genetics laboratories of the Good Health Plan clinic. Overcoming his own personal emotional problems, Jason turns his powers of diagnosis to deduction, vowing to solve the mystery no matter who tries to stop him. His search will take him from gleaming modern labs to seamy sex clubs, from Beacon Hill drawing rooms to the wilds of the Pacific Northwest and back, before the pieces of the deadly puzzle fall into place. By then, Jason has unearthed the scientific breakthrough Hayes was killed to hide — and has himself become the target of a malevolent cabal, bend on using the origins of life to create a hell on earth. With this disturbing story, DNA research is shown to have a fearful potential, not only through possible mistakes and accidents, but ironically even through success. Splendidly researched and intricately plotted, Mortal Fear is Robin Cook at his prophetic and galvanizing best.